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Related Experiment Video

Updated: Feb 23, 2026

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

Platelet RNA in Cancer Diagnostics.

Lee-Ann Tjon-Kon-Fat¹, Nik Sol², Thomas Wurdinger^3,4

¹Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden.

Seminars in Thrombosis and Hemostasis

|September 15, 2017

Summary

Platelets play a key role in cancer metastasis by interacting with tumor cells and altering their RNA. Analyzing platelet biomarkers offers insights into cancer detection, type, and treatment selection for precision medicine.

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Last Updated: Feb 23, 2026

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

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Published on: April 5, 2018

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

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Published on: August 1, 2018

Area of Science:

Oncology
Hematology
Molecular Biology

Background:

Platelets are integral to cancer metastasis, interacting with tumor cells and their microenvironment.
This interaction leads to tumor-mediated 'education' of platelets, altering their RNA profiles and biomolecular content.

Purpose of the Study:

To explore the potential of platelets as a diagnostic and prognostic tool in oncology.
To investigate the utility of platelet RNA profiles and tumor-derived biomarkers for cancer detection and treatment selection.

Main Methods:

Analysis of platelet RNA profiles.
Direct measurement of tumor-derived biomarkers within platelets.

Main Results:

Platelet RNA profiles and biomarkers reflect ongoing cancer-related processes.
This analysis can inform about cancer presence, tumor type, and potentially identify oncogenic drivers.

Conclusions:

Platelets serve as a valuable biosource for precision medicine due to their interaction with cancer.
Assessing platelet biomarkers offers a promising avenue for non-invasive cancer diagnostics and personalized treatment strategies.