Related Experiment Video
Updated: Feb 23, 2026

Working with Human Tissues for Translational Cancer Research
Published on: November 26, 2015
Institutional review boards' attitudes towards remuneration in paediatric research: Ethical considerations
Marius M Flege1, Simon F Thomsen1,2
1Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
Insights
Determining appropriate compensation for pediatric research is crucial. Institutional review boards must balance participant recruitment with ethical considerations when approving payments for child research participants.
Area of Science:
- Pediatric Research Ethics
- Clinical Trial Compensation
- Institutional Review Boards
Background:
- Remuneration for pediatric research participation presents an ethical challenge, requiring careful consideration.
- Excessive payments may lead to undue influence on parental consent, while inadequate compensation can hinder participant recruitment.
Purpose of the Study:
- To explore the factors influencing institutional review boards' (IRBs) decisions regarding remuneration in pediatric research.
- To understand how IRBs evaluate compensation to ensure ethical research practices and adequate participant enrollment.
Main Methods:
- This study examines the ethical considerations and decision-making processes of institutional review boards.
- The research focuses on the specific context of compensation for pediatric clinical trials.
Main Results:
- Little is currently known about the specific factors that guide IRBs in evaluating remuneration for pediatric research.
- The study highlights the complex ethical tightrope IRBs walk when setting compensation levels for child participants.
Conclusions:
- Ethical guidelines and clear criteria are needed for determining appropriate remuneration in pediatric research.
- Further research is necessary to inform IRB best practices for compensation in pediatric trials, ensuring both ethical integrity and successful recruitment.
Abstract:
Remuneration in paediatric research poses an ethical dilemma. Too large a sum might cause parents to enrol their children in research projects with no benefit for the child, whereas too modest a sum might hamper recruitment. The institutional review boards have the responsibility to only approve remuneration in paediatric trials with ethically sound research plans. However, little is known about which factors influence institutional review boards' evaluation of remuneration in paediatric research.
Related Concept Videos
Ethics in Research
Psychosurgery
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Pharmacokinetics in Pediatric Patients: Drug Excretion
Bioavailability Study Design: Healthy Subjects Versus Patients
Ethical Dilemmas I
Let us explore some examples to understand the potentially complex moral decisions nurses face.
Take the case of caring for minors, particularly in areas related to reproductive...
Nursing Ethical Principles II
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...

