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Linkage relationships of X-linked choroideremia to DXYS1 and DXS3
I M MacDonald1, R M Sandre, P Wong
1Department of Biochemistry, Faculty of Health Sciences, University of Ottawa, Ontario, Canada.
Human Genetics
|November 1, 1987
Abstract:
Choroideremia is a distinct blinding condition with an X-linked pattern of inheritance. We have analyzed two RFLPs, DXS3 and DXYS1, for linkage with the choroideremia locus (TCD) within three kindreds. A maximum LOD score of 3.98 was obtained at theta = 0.14 for TCD:DXS3. The summed maximum LOD score from this study and from previously published TCD:DXYS1 data is 5.23 at theta = 0.05. Contrary to previous reports, the present data demonstrate that these two RFLPs are not tightly linked to the choroideremia gene locus.