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Control of hyperprolactinemia with pergolide.

J H Mattox1, J Bernstein, M T Buckman

  • 1Department of Obstetrics and Gynecology and Medicine, University of New Mexico School of Medicine, Albuquerque.

International Journal of Fertility
|January 1, 1986
PubMed
Summary
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Pergolide effectively normalized prolactin levels in patients with prolactinoma, demonstrating superior efficacy and tolerability over bromocriptine. This dopamine agonist offers rapid euprolactinemia and improved compliance for treating prolactinomas.

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Prolactinoma, a pituitary tumor, overproduces prolactin.
  • Dopamine agonists are primary treatments for prolactinoma.

Purpose of the Study:

  • To compare the efficacy and tolerability of bromocriptine and pergolide in treating prolactinoma.

Main Methods:

  • Ten patients with prolactinoma were treated with either bromocriptine (N=6) or pergolide (N=4).
  • Prolactin levels, tumor size, side effects, and compliance were monitored.

Main Results:

  • Both drugs significantly reduced prolactin levels.
  • Pergolide achieved rapid euprolactinemia in all patients at a low dose.
  • Bromocriptine showed an oscillatory prolactin pattern, with 3 patients not reaching euprolactinemia.

Related Experiment Videos

  • Tumor reduction was observed in both groups.
  • Pergolide offered shorter side effect duration and improved compliance.

    • Conclusions:

    • Pergolide is a highly effective and well-tolerated treatment for prolactinoma.
    • Pergolide demonstrates advantages over bromocriptine in achieving and maintaining normal prolactin levels with better patient compliance.