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Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

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Published on: August 20, 2018

Sequential molecule-triggered-release system based on acetylated amylose helix aggregates.

Yongchun Liu¹, Wei Gao, Chunhong Zhang

¹Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China. wudaocheng@mail.xjtu.edu.cn.

Chemical Communications (Cambridge, England)

|September 15, 2017

Summary

Researchers created a new sequential molecule release system using acetylated amylose helix aggregates. This system allows for time-controlled release of loaded molecules triggered sequentially by specific trigger molecules.

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Rapid Generation of Amyloid from Native Proteins In vitro

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Published on: December 5, 2013

Area of Science:

Polymer Chemistry
Materials Science
Drug Delivery Systems

Background:

Acetylated amylose can form helix aggregates.
Controlled release systems are crucial for various applications.
Sequential release mechanisms offer advanced control.

Purpose of the Study:

To develop a novel sequential molecule-triggered-release system.
To utilize acetylated amylose helix aggregates for controlled release.
To achieve time-controllable sequential release of loaded molecules.

Main Methods:

Formation of acetylated amylose helix aggregates with a specific degree of substitution.
Loading of molecules into the helix aggregates.
Sequential triggering of molecule release using trigger molecules with varying binding free energies.

Main Results:

Demonstrated a novel sequential molecule-triggered-release system.
Achieved sensitive and time-controllable triggered release.
Elucidated the mechanism involving sequential displacement based on binding free energy.

Conclusions:

Acetylated amylose helix aggregates provide a viable platform for sequential triggered release.
The system offers precise temporal control over molecular release.
The binding free energy difference is key to the sequential release mechanism.