Morphological studies of human endometrium during continuous LH-RH agonist treatment

Light and electron microscopic studies were performed on endometrial biopsies from seven healthy women after 2 to 17 months of daily intranasal luteinizing hormone-releasing hormone (LH-RH) agonist treatment for contraceptive purposes. Hormone analyses revealed inhibition of ovulation in all the women. Light microscopy showed an inactive or weak proliferative endometrial pattern, with no signs of hyperplasia. Ultrastructurally, the epithelial and stromal cells of the endometrium displayed signs of low metabolic activity. Since the results are contradictory to those earlier presented by others, further studies are necessary to exclude the potential risk of hyperestrogenic stimulation of the endometrium during continuous LH-RH agonist treatment.