Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evaluation of reversible polymorphic phase transitions by thermal analysis.

A C Shah1, N J Britten

  • 1Pharmacy Research, Upjohn Company, Kalamazoo, Michigan 49001.

The Journal of Pharmacy and Pharmacology
|September 1, 1987
PubMed
Summary

Two crystalline forms of an investigational antidiabetic drug, 1,2-dihydro-6-neopentyl-2-oxonicotinic acid, were identified using thermal analysis. Cyclic solid-melt transitions confirmed these polymorphs and their interconversion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk of brainstem necrosis in pediatric patients with central nervous system malignancies after pencil beam scanning proton therapy.

Acta oncologica (Stockholm, Sweden)·2019
Same author

Some Results for the Normal Manova Linear Functional Relationships Model.

Biometrical journal. Biometrische Zeitschrift·2019
Same author

ABO Blood Groups in Leprosy.

Indian journal of dermatology and venereology·2017
Same author

Enhanced antiglioma activity of chimeric HCMV/HSV-1 oncolytic viruses.

Gene therapy·2007
Same author

Bronchoscopic closure of bronchopleural fistula using gelfoam.

The Journal of the Association of Physicians of India·2005
Same author

Pulmonary lymphangioleiomyomatosis.

The Journal of the Association of Physicians of India·2000

Area of Science:

  • Pharmaceutical Sciences
  • Solid-State Chemistry
  • Materials Science

Background:

  • Polymorphism in active pharmaceutical ingredients (APIs) can significantly impact drug stability, solubility, and bioavailability.
  • Understanding crystalline states is crucial for drug development and manufacturing processes.
  • 1,2-dihydro-6-neopentyl-2-oxonicotinic acid is an investigational antidiabetic drug candidate.

Purpose of the Study:

  • To characterize the crystalline forms of 1,2-dihydro-6-neopentyl-2-oxonicotinic acid.
  • To investigate the polymorphic behavior and interconversion of its crystal forms.
  • To evaluate the utility of thermal analysis techniques for polymorphic characterization.

Main Methods:

  • Thermal analyses, including differential scanning calorimetry (DSC), were employed.

Related Experiment Videos

  • Cyclic solid-melt transitions were performed to study phase behavior.
  • Thermogravimetric analysis (TGA) may have been used in conjunction with DSC.
  • Characterization of different drug lots, solvent-recrystallized samples, and mixtures of polymorphs.

    • Main Results:

    • Two distinct polymorphs of 1,2-dihydro-6-neopentyl-2-oxonicotinic acid were identified: Form I (m.p. 193°C) and Form II (m.p. 196°C).
    • Solidification of the melt yielded Form I at 162°C and Form II at 182°C.
    • Form I demonstrated partial conversion to Form II under specific heating conditions with Form II nucleation.
    • DSC thermograms provided clear differentiation between polymorphs and their mixtures.

    Conclusions:

    • Cyclic heat-cool studies are effective for characterizing polymorphic crystal forms of pharmaceutical compounds.
    • The identified polymorphs and their interconversion behavior are critical data for the development of 1,2-dihydro-6-neopentyl-2-oxonicotinic acid.
    • Thermal analysis provides a robust method for quality control and polymorphic assessment in drug manufacturing.