Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Experimental Observation of the Motion of Ions in a Resonantly Driven Plasma Wakefield Accelerator.

Physical review letters·2025

Same author

Filamentation of a relativistic proton bunch in plasma.

Physical review. E·2024

Same author

Hosing of a Long Relativistic Particle Bunch in Plasma.

Physical review letters·2024

Same author

Bone Regeneration in Small and Large Segmental Bone Defect Models after Radiotherapy Using Injectable Polymer-Based Biodegradable Materials Containing Strontium-Doped Hydroxyapatite Particles.

International journal of molecular sciences·2023

Same author

Effect of ischemic preconditioning on skeletal tissue tolerance after warm venous ischemia.

Annales de chirurgie plastique et esthetique·2023

Same author

[Cytosteatonecrosis after breast reconstruction by fat flap with or without ischemic preconditioning].

Annales de chirurgie plastique et esthetique·2023

Search research articles

Related Experiment Video

Updated: Feb 22, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Strontium-doped hydroxyapatite polysaccharide materials effect on ectopic bone formation.

C Ehret¹, R Aid-Launais², T Sagardoy¹

¹Inserm U1026, University of Bordeaux, Tissue Bioengineering, U1026, Bordeaux, France.

|September 15, 2017

Summary

Optimizing hydroxyapatite (HA) content in polysaccharide matrices and incorporating strontium (Sr-HA) enhanced ectopic bone formation. These Sr-HA matrices supported osteoblastic differentiation and induced osteoid tissue and blood vessel growth in vivo.

More Related Videos

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Related Experiment Videos

Last Updated: Feb 22, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Polysaccharide matrices with hydroxyapatite (HA) particles promote ectopic bone formation.
Optimizing HA content and strontium (Sr) doping can enhance matrix bioactivity.

Purpose of the Study:

To optimize HA content in polysaccharide matrices.
To evaluate the effect of strontium-doped HA (Sr-HA) on matrix bioactivity and osteogenesis.

Main Methods:

Subcutaneous implantation of HA-polysaccharide matrices with varying HA ratios.
Chemical characterization and in vitro studies with human mesenchymal stem cells (MSCs).
In vivo subcutaneous implantation of Sr-HA matrices.

Main Results:

A 30% HA to polysaccharide ratio was optimal for ectopic mineralized tissue formation.
Sr-HA matrices showed no cytotoxicity to MSCs and supported osteoblastic differentiation.
In vivo implantation of Sr-HA matrices induced osteoid tissue and blood vessel formation.

Conclusions:

Optimized HA content and Sr-doping significantly enhance the osteogenic potential of polysaccharide matrices.
Sr-HA matrices are promising biomaterials for bone regeneration applications.