Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exon Recombination02:32

Exon Recombination

4.2K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
4.2K
Viral Mutations00:36

Viral Mutations

40.0K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
40.0K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

64.8K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
64.8K
Gene Flow02:39

Gene Flow

38.2K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
38.2K
Genetic Drift03:33

Genetic Drift

44.4K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
44.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative dynamics of Japanese encephalitis virus adaptation in porcine macrophages and insect cells.

Virology journal·2026
Same author

Combining PCR and Metagenomic Approaches to Reveal Tick-Borne Pathogens in Ticks Collected from Livestock and Companion Animals in Cambodia.

Pathogens (Basel, Switzerland)·2026
Same author

Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference.

Nature communications·2026
Same author

In Vitro Analysis and Dynamic Modeling of SARS-CoV-2 Infection Inhibition by Sigma-1 Receptor Antagonist PB28.

Bulletin of mathematical biology·2026
Same author

Concepts of RNA virus evolution for the design of better antiviral countermeasures.

Nature reviews. Microbiology·2026
Same author

Exposure history shapes SARS-CoV-2 viral dynamics in non-human primates and provides insights into correlates of protection against infection and transmission.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026

Related Experiment Video

Updated: Feb 22, 2026

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus
10:35

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus

Published on: May 31, 2020

3.6K

Drivers of Dengue Intrahost Evolution.

Etienne Simon-Lorière1, Marco Vignuzzi2

  • 1Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 75015 Paris, France; CNRS, URA 3012, 75015 Paris, France.

Cell Host & Microbe
|September 15, 2017
PubMed
Summary

RNA viruses evolve quickly within hosts. This study used next-generation sequencing to analyze viral populations during acute dengue infections, offering insights into virus emergence.

More Related Videos

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.2K
Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
08:36

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

32.7K

Related Experiment Videos

Last Updated: Feb 22, 2026

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus
10:35

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus

Published on: May 31, 2020

3.6K
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.2K
Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
08:36

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

32.7K

Area of Science:

  • Virology
  • Evolutionary Biology
  • Infectious Diseases

Background:

  • RNA viruses exist as diverse, evolving variant swarms.
  • Understanding intra-host viral evolution is crucial for predicting virus emergence.

Purpose of the Study:

  • To characterize viral populations within hosts during acute dengue infections.
  • To investigate the evolutionary dynamics of RNA viruses during infection.

Main Methods:

  • Employed next-generation sequencing (NGS) for deep sequencing of viral genomes.
  • Integrated functional studies to assess the impact of viral variants.

Main Results:

  • Detailed characterization of viral genetic diversity in acute dengue.
  • Insights into the evolutionary trajectories of RNA viruses within a host.

Conclusions:

  • Intra-host viral evolution plays a significant role in RNA virus dynamics.
  • Findings contribute to understanding the mechanisms of virus emergence and pathogenesis.