Related Experiment Video
Updated: Feb 22, 2026
Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
Published on: May 15, 2018
Properties of afterdischarges from electrical stimulation in patients with epilepsy
Chang Liu1, Tao Yu1, Zhi-Wei Ren1
1Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Beijing Institute of Functional Neurosurgery, Beijing 100053, China.
Objective:
To investigate the properties of afterdischarges (ADs) from intracerebral electrical stimulation (ES) in patients with epilepsy who underwent stereotactic electroencephalography (SEEG) and determine the relationship between epileptogenic zone (EZ) or irritative zone (IZ) and ADs.
Methods:
We retrospectively analyzed 10 patients with intractable epilepsy who underwent SEEG. ESs were delivered following the given parameters: bipolar, biphasic, 50Hz, 0.2ms pulse duration, 0.5-10mA. The properties of ADs were documented, including their incidence, location, threshold, morphology and evolution.
Results:
A total of 213 ADs (5%) were elicited by 4701 trains of ES. Stimulation through contacts implanted in the hippocampus (59%) generally evoked more ADs than contacts elsewhere (19%). AD thresholds for hippocampal stimulation were significantly lower than those for stimulation in grey matter. Polyspikes (58%) were the most common AD morphology. Evolution occurred more commonly with sequential spikes (47%) than with other AD morphologies (14%). There was no significant correlation between the location of ADs and EZ. However, ADs were significantly more frequently localized to IZ than areas outside IZ (P<0.05).
Conclusions:
There seemed to be a lack of correlation between the location of ADs and EZ. However, ADs were more likely to be elicited in IZ.
More Related Videos
07:31Preparation of Acute Human Hippocampal Slices for Electrophysiological Recordings
Published on: May 7, 2020
06:28Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems
Published on: September 27, 2024
Related Concept Videos
01:24Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
01:30Electroconvulsive Therapy