Binding Isotope Effects for Interrogating Enzyme-Substrate Interactions

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Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects
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Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects

Published on: February 18, 2014

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Christopher F Stratton1, Myles B Poulin1, Vern L Schramm1

  • 1Albert Einstein College of Medicine, Bronx, NY, United States.

Methods in Enzymology
|September 16, 2017
PubMed

Keywords:
Analysis of binding isotope effectsCatalytic site distortionEquilibrium dialysisGround-state stabilizationInhibitor binding effectsMolecular distortionTransition-state analysis

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