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Circulating immunoreactive somatostatin in gastrointestinal diseases. Decrease after vagotomy and enhancement in
J Binimelis1, S M Webb, J Monés
1Dept. of Endocrinology and Nutrition, Hospital de Sant Pau, Autonomous University, Barcelona, Spain.
Scandinavian Journal of Gastroenterology
|October 1, 1987
Summary
Circulating immunoreactive somatostatin (IRS) levels increase after meals. Gastrointestinal diseases like duodenal ulcers and ulcerative colitis show higher IRS responses, suggesting a role for vagal innervation and gut conditions in IRS regulation.
Area of Science:
- Gastroenterology
- Endocrinology
- Physiology
Background:
- The gastrointestinal tract is the primary source of circulating immunoreactive somatostatin (IRS).
- Understanding IRS regulation in gastrointestinal diseases is crucial due to somatostatin's role in gut function.
Purpose of the Study:
- To investigate plasma IRS levels in patients with various gastrointestinal diseases.
- To explore the relationship between gastrointestinal conditions, vagal innervation, and postprandial IRS response.
Main Methods:
- Measured plasma IRS levels in patients with duodenal ulcer, active/inactive ulcerative colitis, irritable bowel syndrome, and gastric ulcer.
- Compared postprandial IRS increments in patients versus age-matched controls.
- Assessed the effect of vagotomy on postprandial IRS response in duodenal ulcer patients.
Main Results:
- A postprandial IRS rise was observed in all subjects.
- Significantly higher postprandial IRS increments were found in duodenal ulcer, active ulcerative colitis, and irritable bowel syndrome patients.
- Vagotomy in duodenal ulcer patients reduced the postprandial IRS increment.
- No significant differences in postprandial IRS were observed in gastric ulcer or inactive ulcerative colitis patients compared to controls.
Conclusions:
- Vagal innervation influences postprandial IRS stimulation.
- Gastric hyperacidity, acute colonic lesions, and gastrointestinal hypermotility are associated with exaggerated postprandial IRS.
- Variations in circulating IRS may have pathophysiological significance in gastrointestinal disorders.