Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.2K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.2K
Stem Cell Culture01:17

Stem Cell Culture

6.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Characteristics and Treatment Patterns of Hyperhidrosis in Northern Hokkaido: A Single-Center Retrospective Descriptive Study.

The Journal of dermatology·2026
Same author

Recurrent Cutaneous Eosinophilic Vasculitis: A Systematic Review of Clinicopathologic Features and Treatment Outcomes.

Acta dermato-venereologica·2026
Same author

Prior Specific Biologic Use as a Potential Risk Factor for Administration-related Reactions to Ixekizumab after Excipient Modification: A Single-centre Retrospective Study.

Acta dermato-venereologica·2026
Same author

Ectopic Insulin-Derived Amyloidosis Arising in the Inguinal Region Distant From Injection Sites.

The Journal of dermatology·2026
Same author

Filamin-ETV4/5 acts as mechanosensor-mechanotransducer axis that drives cell competition-mediated elimination of transformed cells.

Nature communications·2026
Same author

Development of a Novel Risk Assessment Scale to Improve the Consistency and Reliability of Risk-Based Approaches in Clinical Trials.

Therapeutic innovation & regulatory science·2026

Related Experiment Video

Updated: Feb 22, 2026

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia
09:11

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Published on: January 23, 2009

12.3K

Stem cell-based peripheral vascular regeneration.

Yasuyuki Fujita1, Atsuhiko Kawamoto1

  • 1Division of Vascular Regeneration, Unit of Regenerative Medicine, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation, Japan; Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Japan.

Advanced Drug Delivery Reviews
|September 16, 2017
PubMed
Summary
This summary is machine-generated.

Stem cell therapies show promise for critical limb ischemia (CLI), an advanced stage of peripheral arterial disease (PAD). While early trials suggest safety and efficacy, more late-phase studies are needed to confirm benefits for patients ineligible for traditional treatments.

Keywords:
AngiogenesisCell therapyCritical limb ischemiaNeovascularizationPeripheral artery diseaseVasculogenesis

More Related Videos

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

12.7K
Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.1K

Related Experiment Videos

Last Updated: Feb 22, 2026

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia
09:11

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Published on: January 23, 2009

12.3K
Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

12.7K
Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.1K

Area of Science:

  • Regenerative Medicine
  • Vascular Biology
  • Cell-Based Therapies

Background:

  • Chronic critical limb ischemia (CLI) is an advanced stage of peripheral arterial disease (PAD), carrying high risks of amputation and mortality.
  • Many CLI patients cannot undergo conventional revascularization, necessitating alternative strategies to restore blood flow.

Purpose of the Study:

  • To review preclinical and clinical evidence on cell-based therapies for CLI.
  • To assess the utility and limitations of stem/progenitor cell applications in treating CLI.

Main Methods:

  • Review of preclinical research and clinical trial data.
  • Analysis of studies focusing on proangiogenic therapies, including gene/protein therapy and stem/progenitor cells.

Main Results:

  • Somatic stem/progenitor cells, such as bone marrow-derived endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs), have emerged as promising therapeutic options.
  • Early-phase clinical trials indicate that stem/progenitor cell therapies are potentially safe, feasible, and effective for CLI.

Conclusions:

  • Cell-based therapies represent a significant advancement in therapeutic angiogenesis for CLI.
  • Further late-phase clinical trials are essential to validate the long-term efficacy and fully understand the limitations of these innovative treatments.