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MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents

Ilaria Peluso1, Nagendra Sastry Yarla2, Roberto Ambra1

  • 1Research Centre for Food and Nutrition, Council for Agricultural Research and Economics (CREA-AN), Rome, Italy.

Seminars in Cancer Biology
|September 16, 2017
PubMed

Insights

Dietary virgin olive oil and its phytochemicals may target stress-activated mitogen-activated protein kinases (MAPKs) involved in cancer. Olive-derived compounds show potential as cancer prevention agents and chemotherapy adjuvants.

Area of Science:

  • Molecular Biology
  • Oncology
  • Nutritional Science

Background:

  • Mitogen-activated protein kinases (MAPKs) are crucial in inflammation and cancer, regulating proliferation, apoptosis, and immune escape.
  • Current MAPK-targeting therapies face challenges like adverse effects and paradoxical pathway activation.
  • Dietary factors can modulate cancer initiation and progression by interacting with MAPKs.

Purpose of the Study:

  • To review studies on the effects of olive-derived foodstuffs and nutraceuticals on MAPK signaling cascades.
  • To explore the potential of virgin olive oil (VOO) and its components in cancer prevention and therapy.

Main Methods:

  • Literature review of experimental studies investigating olive-derived compounds and MAPK pathways.
  • Analysis of the role of virgin olive oil's squalene content in drug delivery and phytochemical interaction.

Main Results:

  • Experimental studies suggest stress-activated JNK and p38 MAPKs are potential targets of olive-derived nutraceuticals.
  • Phytochemicals from olive cultivation and processing wastes may act as adjuvants in chemotherapy.
  • Virgin olive oil, rich in squalene, shows potential as a natural delivery system for bioactive phytochemicals.

Conclusions:

  • Olive-derived nutraceuticals, including phytochemicals, may modulate MAPK signaling, offering therapeutic potential in cancer.
  • Virgin olive oil serves as a natural delivery system for bioactive compounds, supporting cancer prevention and treatment strategies.
Keywords:
CancerImmunityMitogen-activated protein kinaseOlive productsOxidative stress

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