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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Updated: Feb 22, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
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Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.

Thomas E Sharp1, Giana J Schena1, Alexander R Hobby1

  • 1From the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).

Circulation Research
|September 16, 2017
PubMed
Summary
This summary is machine-generated.

Cortical bone stem cells (CBSCs) improved heart function after myocardial infarction (MI) in a large animal model. CBSC treatment reduced scar size and preserved ejection fraction, offering potential for heart failure treatment.

Keywords:
cell therapyhemodynamicsmyocardial infarctionstem cellsswineventricular remodeling

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Area of Science:

  • Cardiovascular Research
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Cortical bone stem cells (CBSCs) demonstrated efficacy in reducing ventricular remodeling and improving cardiac function in murine myocardial infarction (MI) models.
  • CBSC effects surpassed other stem cell types used in early clinical trials.
  • Previous studies lacked preclinical validation in large animal models for patient-relevant approaches.

Purpose of the Study:

  • To evaluate the efficacy of transendocardial injection of allogeneic CBSCs in reducing pathological remodeling and preventing heart failure post-MI in a swine model.
  • To assess the impact of CBSCs on cardiac structure and function following induced myocardial infarction.

Main Methods:

  • Swine underwent ischemia-reperfusion MI via left anterior descending coronary artery occlusion.
  • Animals received randomized, blinded transendocardial injections of CBSCs (n=9) or placebo (vehicle; n=9).
  • Cardiac structure and function were assessed using serial echocardiography and invasive hemodynamics at 3 months post-MI, with initial injury and cell retention evaluated at 72 hours.

Main Results:

  • CBSCs were detected and proliferating in the MI border zone at 72 hours but did not affect initial injury.
  • At 3 months, CBSC treatment significantly reduced scar size, decreased myocyte size, and increased myocyte nuclear density.
  • Left ventricular volumes and ejection fraction were better preserved in CBSC-treated hearts, with improved cardiac functional reserve.

Conclusions:

  • CBSC administration into the MI border zone effectively mitigates pathological cardiac remodeling.
  • Treatment improves left ventricular functional reserve and reduces processes leading to heart failure with reduced ejection fraction.
  • CBSCs represent a promising therapeutic strategy for post-myocardial infarction recovery.