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Lower Plasma Fetuin-A Levels Are Associated With a Higher Mortality Risk in Patients With Coronary Artery Disease

Xuechen Chen1, Yuan Zhang1, Qian Chen1

  • 1From the Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China (X.C., Q.C., Y.L., W.L.); Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China (X.C., Q.C., Y.L., W.L.); Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, China (Y.Z.); and Department of Epidemiology, School of Public Health, Guilin Medical University, China (Q.L.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|September 16, 2017
PubMed

Insights

Lower levels of circulating fetuin-A are linked to higher risks of cardiovascular disease (CVD) and death in patients with coronary artery disease. This finding holds true even when considering traditional CVD risk factors.

Area of Science:

  • Biochemistry
  • Cardiology
  • Epidemiology

Background:

  • Cardiovascular disease (CVD) remains a leading cause of mortality worldwide.
  • Identifying novel biomarkers for CVD risk stratification is crucial for improving patient outcomes.
  • Fetuin-A, a circulating protein, has been implicated in metabolic and cardiovascular health.

Purpose of the Study:

  • To investigate the association between plasma fetuin-A levels and the risk of cardiovascular disease (CVD) mortality.
  • To evaluate the relationship between plasma fetuin-A and all-cause mortality in patients with coronary artery disease.

Main Methods:

  • Plasma fetuin-A levels were measured using an enzyme-linked immunosorbent assay (ELISA) in 1620 patients from the Guangdong coronary artery disease cohort.
  • Cox regression models were employed to analyze the association between fetuin-A levels and mortality outcomes.
  • Follow-up data were collected for a median of 5.9 years, during which 206 deaths occurred.

Main Results:

  • Lower plasma fetuin-A levels were significantly associated with increased risk of both CVD and all-cause mortality.
  • The hazard ratios for CVD mortality were 0.65 and 0.51 for the second and third tertiles of fetuin-A, respectively (P=0.005).
  • The hazard ratios for all-cause mortality were 0.65 and 0.48 for the second and third tertiles of fetuin-A, respectively (P<0.001).

Conclusions:

  • Lower circulating fetuin-A levels are an independent predictor of increased risk for all-cause and CVD mortality in patients with coronary artery disease.
  • These findings suggest that fetuin-A may serve as a valuable prognostic biomarker in cardiovascular disease management.
  • Further research is warranted to elucidate the underlying mechanisms linking fetuin-A to cardiovascular outcomes.
Abstract

Keywords:
alpha-2-HS-glycoproteincoronary artery diseasefollow-up studieshumansrisk factors

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