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Immune responses in the thyroid cancer microenvironment: making immunotherapy a possible mission

Robert C Mould1, Jacob P van Vloten1, Amanda W K AuYeung1

  • 1Department of PathobiologyOntario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

Endocrine-Related Cancer
|September 16, 2017
PubMed

Insights

Thyroid cancer incidence is rising, with poor outcomes for advanced disease. This review explores cancer immunotherapy as a novel treatment by examining thyroid cancer

Area of Science:

  • Oncology
  • Immunology
  • Endocrinology

Background:

  • Thyroid cancer incidence is increasing globally.
  • Differentiated thyroid cancers have high survival rates, but undifferentiated, recurrent, or metastatic disease have poor outcomes.
  • Novel therapeutic strategies are needed for advanced thyroid cancers.

Purpose of the Study:

  • To review the immunological landscape of thyroid cancers.
  • To discuss the modulation of thyroid cancer immunity.
  • To explore the potential of cancer immunotherapy in thyroid cancer treatment.

Main Methods:

  • Literature review of thyroid cancer immunology and immunotherapy.
  • Analysis of immunological consequences of conventional therapies.
  • Examination of hormonal modulation of the immune system in thyroid cancer.

Main Results:

  • The thyroid cancer microenvironment is immunologically active.
  • Conventional therapies can have unexpected immunological effects.
  • Hormonal factors uniquely influence thyroid cancer immunity.

Conclusions:

  • Cancer immunotherapy holds promise for thyroid cancer, especially for advanced disease.
  • Understanding thyroid cancer's unique immunological features is crucial for effective treatment.
  • Integration of immunotherapy with standard care and further research are high priorities.
Keywords:
immune systemimmunotherapythyroidthyroid cancers

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