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Wilson's disease presenting with HELLP syndrome; A case report
Sümeyra Nergiz Avcıoğlu1, Sündüz Özlem Altınkaya1, Mert Küçük2
1Adnan Menderes University Faculty of Medicine, Department of Gynecology and Obstetrics, Aydın, Turkey.
Turkish Journal of Obstetrics and Gynecology
|September 16, 2017
Summary
Wilson's disease, a genetic disorder of copper metabolism, can mimic HELLP syndrome in pregnancy. Early diagnosis is crucial for managing liver failure in these complex cases.
Area of Science:
- Hepatology
- Genetics
- Obstetrics
Background:
- Wilson's disease (WD) is an inherited disorder of copper metabolism, leading to toxic copper accumulation primarily in the liver and brain.
- Hepatic manifestations of WD range from asymptomatic enzyme elevation to acute liver failure.
Observation:
- Acute liver failure in WD can present with intravascular hemolytic anemia and thrombocytopenia, mimicking HELLP syndrome.
- This presentation poses diagnostic challenges, especially during pregnancy.
Findings:
- The case highlights WD in pregnancy presenting with HELLP-like symptoms, progressing to acute liver failure postpartum.
- Differential diagnosis between WD and HELLP syndrome is critical.
Implications:
- Recognizing WD's potential to mimic HELLP syndrome is vital for timely and accurate diagnosis in pregnant patients.
- This case underscores the importance of considering rare genetic disorders in obstetric emergencies.
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