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Wilson's disease presenting with HELLP syndrome; A case report.

Sümeyra Nergiz Avcıoğlu1, Sündüz Özlem Altınkaya1, Mert Küçük2

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Wilson's disease, a genetic disorder of copper metabolism, can mimic HELLP syndrome in pregnancy. Early diagnosis is crucial for managing liver failure in these complex cases.

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Area of Science:

  • Hepatology
  • Genetics
  • Obstetrics

Background:

  • Wilson's disease (WD) is an inherited disorder of copper metabolism, leading to toxic copper accumulation primarily in the liver and brain.
  • Hepatic manifestations of WD range from asymptomatic enzyme elevation to acute liver failure.

Observation:

  • Acute liver failure in WD can present with intravascular hemolytic anemia and thrombocytopenia, mimicking HELLP syndrome.
  • This presentation poses diagnostic challenges, especially during pregnancy.

Findings:

  • The case highlights WD in pregnancy presenting with HELLP-like symptoms, progressing to acute liver failure postpartum.
  • Differential diagnosis between WD and HELLP syndrome is critical.

Implications:

  • Recognizing WD's potential to mimic HELLP syndrome is vital for timely and accurate diagnosis in pregnant patients.
  • This case underscores the importance of considering rare genetic disorders in obstetric emergencies.