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Related Concept Videos

The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

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The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
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The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
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In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Spindle Cell Lipoma: A Rare, Misunderstood Entity.

Bommie Florence Seo1, In Sook Kang1, Deuk Young Oh1

  • 1Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Archives of Craniofacial Surgery
|September 16, 2017
PubMed
Summary
This summary is machine-generated.

Spindle cell lipoma is a rare benign tumor typically found on the neck or shoulder. This case highlights an atypical presentation in the supraclavicular area, emphasizing its importance in soft tissue mass differential diagnosis.

Keywords:
Atypical lipomaHead and neck tumorRare diseases

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Area of Science:

  • Dermatology
  • Surgical Pathology
  • Oncology

Background:

  • Spindle cell lipoma (SCL) is a rare variant of lipoma, characterized by mature adipocytes and a proliferation of spindle-shaped cells.
  • These benign tumors typically occur in the posterior neck and shoulder region of middle-aged to older men.
  • Atypical presentations can pose diagnostic challenges, potentially mimicking other soft tissue neoplasms.

Purpose of the Study:

  • To report a case of spindle cell lipoma presenting in an unusual location (supraclavicular area).
  • To discuss the differential diagnosis of soft tissue masses in this region.
  • To emphasize the importance of considering SCL in the differential diagnosis of newly identified soft tissue masses.

Main Methods:

  • Clinical presentation of a 24-year-old male with a large, firm, nodular mass in the right supraclavicular area.
  • Surgical excision of the mass.
  • Gross pathological examination revealing a pale yellow, rubbery nodule.
  • Histopathological analysis to confirm the diagnosis of spindle cell lipoma.

Main Results:

  • The excised mass was pathologically confirmed as a spindle cell lipoma.
  • The lesion's gross appearance initially suggested a lymphoma, highlighting a potential diagnostic pitfall.
  • The patient had a family history of malignant lymphoma, adding complexity to the initial assessment.

Conclusions:

  • Spindle cell lipoma can occur in atypical locations, such as the supraclavicular area.
  • Despite its rarity and unusual location, SCL should be included in the differential diagnosis of soft tissue masses.
  • Simple excision is curative for spindle cell lipoma, underscoring the importance of accurate diagnosis.