Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bronchodilators: beta 2 agonists versus theophylline.

G W Scott1

  • 1Guy's Hospital, London, United Kingdom.

Annals of the Academy of Medicine, Singapore
|April 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

QUININE PROPHYLAXIS IN MALARIA.

British medical journal·2010
Same author

EPIDEMIC PNEUMONIC INFLUENZA AS SEEN IN MALAYA.

British medical journal·2010
Same author

Piezoelectrically tuned short-cavity dye-laser design.

Applied optics·2010
Same author

Prolonged labor, with special reference to postpartum hemorrhage.

Journal of the American Medical Association·2010
Same author

Contacted mode-locking-dye cell.

Applied optics·2010
Same author

Short-cavity picosecond dye laser design.

Applied optics·2010
Same journal

"Gazing into the crystal ball of mortality prediction in conservative kidney care": Correspondence.

Annals of the Academy of Medicine, Singapore·2026
Same journal

Vascular stiffness and sepsis mortality: A promising signal in search of clinical relevance.

Annals of the Academy of Medicine, Singapore·2026
Same journal

Transcatheter aortic valve implantation for severe aortic regurgitation with Trilogy system: Initial Southeast Asia experience.

Annals of the Academy of Medicine, Singapore·2026
Same journal

Singapore expert consensus on optimising lipid-lowering strategies in acute coronary syndrome: A modified Delphi study.

Annals of the Academy of Medicine, Singapore·2026
Same journal

Association of estimated pulse wave velocity with 28-day mortality in sepsis: A MIMIC-IV study.

Annals of the Academy of Medicine, Singapore·2026
Same journal

Prognostic value of the monocyte-to-albumin ratio in nasopharyngeal carcinoma: A retrospective cohort study.

Annals of the Academy of Medicine, Singapore·2026
See all related articles

Inhaled beta 2 agonists offer maximum therapeutic effects for asthma with fewer side effects. Theophylline derivatives, while less potent bronchodilators, aid in managing chronic severe asthma, especially nocturnal symptoms.

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Clinical Therapeutics

Background:

  • Inhaled administration of beta 2 agonists maximizes therapeutic effects and minimizes side effects like tachycardia and tremor.
  • Different inhalation devices, including pressurized inhalers, Rotahalers, and nebulizers, are available for beta 2 agonist delivery.
  • Beta 2 agonists may have a suppressive effect and are often administered before inhaled corticosteroids like beclomethasone.

Purpose of the Study:

  • To review the optimal administration routes and therapeutic applications of beta 2 agonists and theophylline derivatives in asthma management.
  • To discuss the role of sustained-release theophylline preparations and plasma level monitoring in optimizing therapy.
  • To highlight the comparative efficacy and specific uses of beta 2 agonists and theophyllines in different asthma severities.

Related Experiment Videos

Main Methods:

  • Review of current literature on the pharmacology and clinical use of beta 2 agonists and theophylline in asthma.
  • Analysis of administration routes, including inhalation devices and their modifications.
  • Examination of theophylline pharmacokinetics, therapeutic ranges, and factors influencing its clearance.

Main Results:

  • Inhaled beta 2 agonists provide superior therapeutic effects with reduced systemic side effects compared to other routes.
  • High doses of beta 2 agonists can be effective in severe chronic asthma unresponsive to conventional doses.
  • Theophylline, though a weaker bronchodilator, offers additive benefits in chronic severe asthma and is effective for nocturnal symptoms.

Conclusions:

  • Inhalation is the preferred route for beta 2 agonist administration in asthma.
  • Beta 2 agonists play a crucial role in both immediate bronchodilation and potentially long-term asthma control.
  • Theophylline remains a valuable option for severe chronic asthma, particularly for managing nocturnal symptoms, with optimized therapy through sustained-release formulations and plasma monitoring.