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Changes of cortical connectivity during deep anaesthesia.

Bogdan Pavel1, Camelia Alexandra Acatrinei1, Fabien Menardy2

  • 1"Carol Davila" University of Medicine and Pharmacy, Division of Physiology and Fundamental Neurosciences, Bucharest, Romania.

Romanian Journal of Anaesthesia and Intensive Care
|September 16, 2017
PubMed
Summary

Frontal intracortical connectivity increased during burst periods of deep anesthesia compared to suppression and slow wave periods. This suggests enhanced cortical synchronization may originate from subcortical structures.

Keywords:
anaesthesiaburst suppressioncortical connectivity

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Area of Science:

  • Neuroscience
  • Anesthesiology
  • Computational Neuroscience

Background:

  • Deep anesthesia, characterized by burst-suppression patterns, significantly alters brain activity.
  • Understanding cortical connectivity under anesthesia is crucial for surgical safety and brain function research.

Purpose of the Study:

  • To investigate frontal intracortical connectivity during deep anesthesia, specifically during burst-suppression patterns.
  • To compare cortical synchronization during burst, suppression, and slow wave anesthesia periods.

Main Methods:

  • Experiments conducted on adult Sprague Dawley rats under isoflurane-induced anesthesia.
  • Local field potentials recorded from the frontal cortex using stereotactic electrode insertion.
  • Cortical connectivity assessed via coherence spectra analysis during different anesthetic states.

Main Results:

  • Global cortical connectivity (0.5-100 Hz) was significantly higher during burst periods (0.61 ± 0.078) compared to suppression (0.55 ± 0.032) and slow wave (0.55 ± 0.015) anesthesia (p < 0.05).
  • A notable increase in cortical synchronization was observed during burst periods.

Conclusions:

  • Global cortical connectivity is enhanced during the burst periods of deep anesthesia.
  • The observed increase in synchronization may be attributed to subcortical influences on cortical activity during bursts.