Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Composition of Polyprotic Acid Solutions as a Function of pH01:19

Composition of Polyprotic Acid Solutions as a Function of pH

910
Polyprotic acids of the type H2M constitute two ionizable protons. As a result, on titration with a base, they exhibit two equivalence points in the titration curve. During titration, the species H2M, HM−, and M2− will be present in the solution at different points. The fractions of H2M, HM−, and M2− present at the various instances of the titration are denoted by α0, α1, and α2, respectively.
A graph with the alpha values is plotted against the volume of...
910
Polyprotic Acids03:38

Polyprotic Acids

32.3K
Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
32.3K
Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

3.3K
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
3.3K
Structures of Carboxylic Acid Derivatives01:28

Structures of Carboxylic Acid Derivatives

3.8K
Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
3.8K
Prochirality02:05

Prochirality

5.1K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
5.1K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

15.3K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
15.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Construction of nicotinic acid derived bimetallic doped Ce-MOF with switchable dual enzyme-mimic activities for effective colorimetric sensing of chromium(Ⅵ) and fluoride ions.

Talanta·2026
Same author

High COMP expression promotes tumor cell proliferation and migration of rectal cancer, contributing to unfavorable prognosis and suppressive immune microenvironment.

Discover oncology·2026
Same author

Phenylboronic acid decorated SiO<sub>2</sub>@Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticle coupled with peroxidase-like Au,Pt,Cu@polydopamine immunoprobe based sandwich approach for the detection of transferrin.

Talanta·2025
Same author

A facile colorimetric sensor based on Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles with intrinsic catalytic activity for the rapid and selective detection of ochratoxin A.

Food chemistry·2025
Same author

RBB1 negatively regulates rice disease resistance by modulating protein glycosylation.

Journal of integrative plant biology·2024
Same author

Existing Forms of Notoginsenoside R<sub>1</sub> in Rats and Their Potential Bioactivities.

Journal of agricultural and food chemistry·2024

Related Experiment Video

Updated: Feb 22, 2026

Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight MALDI-TOF Mass Spectrometry
06:56

Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight MALDI-TOF Mass Spectrometry

Published on: June 10, 2018

26.3K

[Polymorphism of shikimic acid].

Feng-Feng Wang1, De-Zhi Yang1, Yang Lv1

  • 1Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|September 16, 2017
PubMed
Summary
This summary is machine-generated.

This study identified three novel crystal forms of shikimic acid (SA) through optimized recrystallization. X-ray powder diffraction (PXRD) proved essential for distinguishing these solid-state forms.

Keywords:
detection methodpolymorphismquality controlshikimic acid

More Related Videos

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.3K
A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
11:08

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

Published on: December 9, 2017

7.4K

Related Experiment Videos

Last Updated: Feb 22, 2026

Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight MALDI-TOF Mass Spectrometry
06:56

Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight MALDI-TOF Mass Spectrometry

Published on: June 10, 2018

26.3K
Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.3K
A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
11:08

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

Published on: December 9, 2017

7.4K

Area of Science:

  • Solid-state chemistry
  • Crystallography
  • Pharmaceutical sciences

Background:

  • Shikimic acid (SA) is a crucial precursor in pharmaceutical synthesis.
  • Understanding SA's solid-state properties, including polymorphism, is vital for drug development and manufacturing.
  • Polymorphism can significantly impact a compound's stability, solubility, and bioavailability.

Purpose of the Study:

  • To systematically investigate and characterize the polymorphism of shikimic acid.
  • To discover and prepare new crystalline forms of SA.
  • To establish an effective method for qualitative analysis of SA polymorphs.

Main Methods:

  • Optimization of recrystallization parameters (solvent, volume, temperature, time, pressure).
  • Characterization using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray powder diffraction (PXRD), and infrared spectrometry (IR).
  • Exploration of stability and transformation pathways using influencing factor experiments.

Main Results:

  • Three new crystalline forms (polymorphs) of shikimic acid were successfully prepared and identified.
  • X-ray powder diffraction (PXRD) was the definitive method for distinguishing between the identified polymorphs.
  • No solvent was detected in any of the three crystal forms, indicating they are true polymorphs.
  • The composition, thermodynamic properties, and interconversion of these polymorphs were elucidated.

Conclusions:

  • The study successfully identified and characterized three novel polymorphisms of shikimic acid.
  • PXRD is confirmed as the most reliable technique for differentiating these SA solid forms.
  • An effective qualitative analysis method for shikimic acid polymorphs was established, aiding in pharmaceutical quality control.