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Update: Topical Antimicrobial Agents for Chronic Wounds.

R Gary Sibbald1, James A Elliott, Luvneed Verma

  • 1R. Gary Sibbald, MD, DSc (Hons), MEd, BSc, FRCPC (Med)(Derm), FAAD, MAPWCA • Professor • Medicine and Public Health • University of Toronto • Toronto, Ontario, Canada • Director • International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care) • Dalla Lana Faculty of Public Health • University of Toronto • Past President • World Union of Wound Healing Societies • Clinical Editor • Advances in Skin & Wound Care • Philadelphia, Pennsylvania James A. Elliott • Faculty • International Interprofessional Wound Care Course • Member • Wounds Canada Research Committee • Trustee • T1 International • United Kingdom Luvneed Verma, MAcc, BSc, MDc • Medical Student • University of Ottawa • Ottawa, Ontario, Canada Alisa Brandon, MSc, BSc • Medical Student • University of Toronto • Toronto, Ontario, Canada Reneeka Persaud • Faculty • International Interprofessional Wound Care Course • Research Coordinator • WoundPedia • Canada Elizabeth A. Ayello, PhD, RN, ACNS-BC, CWON, ETN, MAPWCA, FAAN • Faculty • Excelsior College School of Nursing • Albany, New York • President • Ayello Harris & Associates, Inc • Copake, New York • Clinical Editor • Advances in Skin & Wound Care • Philadelphia, Pennsylvania.

Advances in Skin & Wound Care
|September 16, 2017
PubMed
Summary

Topical antimicrobial agents are crucial for managing chronic wounds by preventing bacterial interference with healing. This review guides healthcare professionals on their appropriate use, considering efficacy and safety.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Chronic wounds present a significant challenge in healthcare, with bacterial colonization frequently impeding the healing process.
  • Superficial wound infections require effective management to prevent deeper tissue invasion and systemic complications.
  • Topical antimicrobial therapies are a cornerstone in the treatment of superficial chronic wound infections.

Purpose of the Study:

  • To provide comprehensive information on the application of topical antimicrobial agents for chronic wound treatment.
  • To equip healthcare professionals with the knowledge to select appropriate agents and manage potential adverse effects.
  • To synthesize current evidence and expert opinion on topical antimicrobial use in wound care.

Main Methods:

  • Systematic review of published evidence from 2012-2017.
  • Critical appraisal and synthesis of recent literature.
  • Extrapolation of findings to clinical practice, incorporating expert opinion and patient-centered concerns.

Main Results:

  • Evidence tables summarizing commonly used topical antimicrobials are provided.
  • Discussion includes therapeutic benefits and potential adverse effects of various agents.
  • Focus remains on the superficial compartment of chronic wounds.

Conclusions:

  • Appropriate selection and application of topical antimicrobial agents are vital for effective chronic wound management.
  • Understanding the evidence base and potential risks associated with these agents is crucial for optimal patient outcomes.
  • This review serves as a guide for healthcare professionals in the skin and wound care field.