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Published on: April 13, 2010
[Allergic bronchopulmonary aspergillosis in patients with asthma: Results of a prospective study]
Ya I Kozlova1, E V Frolova1, L V Filippova1
1I.I. Mechnikov North-Western State Medical University Ministry of Health of Russia, Saint Petersburg, Russia.
Aim:
To estimate the frequency of fungal sensitization and the incidence of allergic bronchopulmonary aspergillosis (ABPA) in asthmatic patients.
Subjects And Methods:
A total of 140 asthmatic patients were examined. They underwent allergologic (skin tests for fungal allergens, estimation of total and fungal allergen-specific IgE levels) and mycological (microscopy and inoculation of respiratory biosubstrates) examinations. Chest computed tomography, when indicated, was done. A group of patients with ABPA and that of patients with severe asthma and fungal sensitization were identified.
Results:
The frequency of fungal sensitization in asthmatic patients was 36%; the main allergenic fungi were Aspergillus and Alternaria. The incidence of ABPA was as high as 4% in the patients with asthma and 11% in those with severe asthma and fungal sensitization.
Conclusion:
The given current diagnostic criteria will assist practitioners to identify ABPA, to prevent its progression, and to initiate specific anti-inflammatory and antifungal therapy in due time.
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