[Giant cell arteritis: Genetic and epigenetic aspects].

Area of Science:

• Rheumatology
• Genetics
• Epigenetics

Background:

• Giant cell arteritis (GCA) is a systemic vasculitis primarily affecting large and medium arteries.
• GCA typically presents in individuals over 50 years old, with a predilection for women.
• The etiology of GCA remains incompletely understood, with suspected genetic and environmental components.

Observation:

• This paper details clinical observations of two brothers diagnosed with giant cell arteritis.
• The familial occurrence suggests a potential genetic predisposition or shared environmental factors.

Findings:

• The study investigates the genetic and epigenetic underpinnings of giant cell arteritis in affected siblings.
• Analysis includes a review of existing Russian and international literature on GCA genetics and epigenetics.

Implications:

• Understanding the genetic and epigenetic factors in familial GCA may offer insights into disease pathogenesis.
• This research could contribute to identifying novel diagnostic markers or therapeutic targets for giant cell arteritis.