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Articles linked to this work by shared authors, journal, and citation graph.

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Early-Stage Perfusion MRI Correlates Significantly With Femoral Head Deformity in Children Under 6 Years of Age With Legg-Calvé-Perthes Disease: A Preliminary Multicenter Study.

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Ischemic femoral head osteonecrosis in a piglet model causes three dimensional decrease in acetabular coverage.

Vidyadhar V Upasani1,2, Megan E Jeffords1, Christine L Farnsworth1

  • 1Rady Children's Hospital, San Diego, California.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|September 16, 2017
PubMed
Summary

Legg-Calve-Perthes disease (LCPD) in piglets causes femoral head deformity and predictable acetabular changes. This piglet model reveals how LCPD affects both the femur and acetabulum, aiding future research.

Keywords:
3-D acetabular coverage angleLegg-Calve-Perthes diseasecomputed tomographyfemoral head deformityfemoral head osteonecrosisischemic osteonecrosis of the femoral headpiglet model of Perthes disease

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Area of Science:

  • Orthopedics
  • Pediatric Orthopedics
  • Biomechanical Engineering

Background:

  • Legg-Calve-Perthes disease (LCPD) is a childhood condition causing femoral head deformity and early osteoarthritis.
  • Previous research on LCPD has primarily focused on femoral head changes, neglecting the acetabulum.

Purpose of the Study:

  • To investigate acetabular alterations in a piglet model of LCPD.
  • To characterize acetabular changes using 3-D CT and modeling.

Main Methods:

  • Surgically induced ischemic osteonecrosis in 24 piglets, with contralateral hips as controls.
  • CT imaging at 8 weeks postoperative.
  • Custom software for measuring acetabular morphologic parameters on 3-D CT.

Main Results:

  • Significant decreases in acetabular version and tilt (p < 0.001) were observed.
  • Reduced superior, posterior, and inferior quadrant coverage angles (p < 0.05) accompanied femoral head deformities.
  • The piglet model demonstrated acetabular changes consistent with those seen in human LCPD patients.

Conclusions:

  • Femoral head deformity in LCPD leads to specific, predictable acetabular shape changes.
  • The piglet model effectively replicates LCPD-associated acetabular deformities.
  • This model is valuable for studying the relationship between femoral head and acetabular deformities in LCPD.