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Related Experiment Video

Updated: Feb 22, 2026

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Vitamin D in obesity.

Jennifer S Walsh1, Simon Bowles, Amy L Evans

  • 1Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK.

Current Opinion in Endocrinology, Diabetes, and Obesity
|September 16, 2017
PubMed
Summary
This summary is machine-generated.

Lower vitamin D levels in obese individuals may be due to dilution, not deficiency. Obese people require higher vitamin D doses for adequate serum levels, but often maintain good bone health.

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Bone Metabolism

Background:

  • Vitamin D is crucial for bone health and immune function.
  • Vitamin D deficiency is prevalent, with increasing testing and supplementation.
  • Obesity is associated with lower serum vitamin D levels, necessitating investigation into the underlying mechanisms and clinical significance.

Purpose of the Study:

  • To investigate the reasons for lower serum vitamin D in obese individuals.
  • To determine if lower vitamin D in obesity indicates clinically significant deficiency.
  • To understand the impact of obesity on vitamin D distribution and bone health.

Main Methods:

  • Review of existing literature on vitamin D metabolism, obesity, and bone health.
  • Analysis of vitamin D distribution in various body compartments (fat, muscle, liver, serum).
  • Comparison of bone turnover markers and bone mineral density in obese versus normal-weight individuals.

Main Results:

  • Vitamin D, being fat-soluble, distributes into increased body compartments in obesity, suggesting a volumetric dilution effect.
  • Despite lower serum vitamin D, obese adults do not exhibit increased bone turnover or reduced bone mineral density.
  • Patients undergoing bariatric surgery may experience bone loss, potentially mitigated by ensuring vitamin D sufficiency.

Conclusions:

  • Lower serum vitamin D in obese individuals is a consistent observation across diverse populations.
  • This finding does not always signify a clinical deficiency or problem.
  • Obese individuals require higher initial doses (loading doses) of vitamin D to achieve target serum 25-hydroxyvitamin D concentrations comparable to normal-weight individuals.