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Trace Elements and Healthcare: A Bioinformatics Perspective.

Yan Zhang1

  • 1College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518060, Guangdong Province, People's Republic of China. zhangyan@szu.edu.cn.

Advances in Experimental Medicine and Biology
|September 17, 2017
PubMed
Summary

Bioinformatics offers new insights into biological trace elements and their role in human health. This research explores trace element metabolism, function, and disease links using computational methods and ionomics.

Keywords:
BioinformaticsComparative genomicsDiseaseIonomeMetalSystems biologyTrace element

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Human Health

Background:

  • Biological trace elements are vital for human health.
  • Metabolic imbalances in trace elements are linked to various diseases.
  • Bioinformatics research on trace elements is emerging.

Purpose of the Study:

  • To provide an overview of bioinformatics analyses in trace element utilization, metabolism, and function.
  • To discuss the relationship between trace elements and diseases using large-scale studies.
  • To introduce developments in ionomics and its health applications.

Main Methods:

  • Comparative genomics of essential metals.
  • Analysis of genome-wide association studies (GWAS).
  • Review of case-control studies.
  • Exploration of ionomics advancements.

Main Results:

  • Bioinformatics approaches reveal new aspects of trace element metabolism and function.
  • Systematic studies highlight connections between specific elements and diseases.
  • Ionomics provides novel tools for studying trace elements in human health.

Conclusions:

  • Bioinformatics is a valuable tool for understanding trace element biology and disease.
  • Further research integrating computational methods and ionomics is warranted.
  • Trace element homeostasis is crucial for maintaining human health.