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Ventral hernia repair with poly-4-hydroxybutyrate mesh
Margaret A Plymale1, Daniel L Davenport1, Adam Dugan1
1Division of General Surgery, Department of Surgery, C 225, Chandler Medical Center, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY, 40536, USA.
Surgical Endoscopy
|September 17, 2017
Summary
Poly-4-hydroxybutyrate (P4HB) mesh shows promising results for ventral hernia repair, with no recurrence and improved quality of life in patients. This bioresorbable mesh is a feasible option for VIHR.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Regenerative Medicine
Background:
- Biomaterial research has yielded a fully resorbable poly-4-hydroxybutyrate (P4HB) mesh for ventral and incisional hernia repair (VIHR).
- This study investigates the clinical outcomes of patients undergoing VIHR utilizing P4HB mesh.
Purpose of the Study:
- To assess the clinical outcomes and quality of life (QOL) in patients undergoing VIHR with P4HB mesh.
- To evaluate the feasibility and safety of using bioresorbable P4HB mesh in hernia repair.
Main Methods:
- A prospective pilot study involving 31 patients undergoing VIHR with P4HB mesh via a Rives-Stoppa approach.
- Data collected included perioperative characteristics, clinical outcomes, employment status, QOL (SF-12), and pain assessments over 24 months.
Main Results:
- No hernia recurrence was observed in the patient cohort with a median follow-up of 414 days.
- 19% of patients experienced surgical site occurrences, primarily seroma.
- Patients reported significant improvements in QOL, specifically the SF-12 physical component summary and role emotional scores at 24 months (p < 0.05).
Conclusions:
- Ventral hernia repair using P4HB bioresorbable mesh demonstrates favorable outcomes, including zero early recurrence.
- Significant improvements in patient quality of life were noted at 24 months post-surgery.
- P4HB mesh represents a feasible and effective option for VIHR in this patient population.
