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Apparent diffusion coefficient in the analysis of prostate cancer: determination of optimal b-value pair to
Nuno Adubeiro1, Maria Luísa Nogueira2, Rita G Nunes3
1Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Department of Radiology, School of Health of Porto/Polytechnic Institute of Porto (ESS/IPP), Rua Dr. António Bernardino de Almeida 400, 4200-072 Porto, Portugal.
Purpose:
Determining optimal b-value pair for differentiation between normal and prostate cancer (PCa) tissues.
Methods:
Forty-three patients with diagnosis or PCa symptoms were included. Apparent diffusion coefficient (ADC) was estimated using minimum and maximum b-values of 0, 50, 100, 150, 200, 500s/mm2 and 500, 800, 1100, 1400, 1700 and 2000s/mm2, respectively. Diagnostic performances were evaluated when Area-under-the-curve (AUC)>95%.
Results:
15 of the 35 b-values pair surpassed this AUC threshold. The pair (50, 2000s/mm2) provided the highest AUC (96%) with ADC cutoff 0.89×10-3mm2/s, sensitivity 95.5%, specificity 93.2% and accuracy 94.4%.
Conclusions:
The best b-value pair was b=50, 2000s/mm2.
