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Towards personalized medicine of colorectal cancer

Mohammad Azhar Aziz1, Zeyad Yousef2, Ayman M Saleh3

  • 1King Abdullah International Medical Research Center [KAIMRC], King Saud Bin Abdulaziz University for Health Sciences, Colorectal Cancer Research Program, National Guard Health Affairs, P.O. Box 22490, Riyadh 11426, Saudi Arabia.

Critical Reviews in Oncology/Hematology
|September 18, 2017
PubMed

Insights

Colorectal cancer (CRC) research faces challenges due to its complexity. New

Area of Science:

  • Oncology and Molecular Biology
  • Bioinformatics and Computational Biology

Background:

  • Colorectal cancer (CRC) presents significant challenges in early detection and treatment of metastatic stages.
  • The heterogeneous nature of CRC and its diverse molecular pathways complicate research efforts and patient management.

Purpose of the Study:

  • To review current challenges in colorectal cancer management.
  • To explore how emerging 'omics' technologies and computational analyses can advance personalized medicine for CRC.

Main Methods:

  • Review of current literature on colorectal cancer research.
  • Discussion of advancements in large-scale 'omics' technologies (genomics, proteomics, etc.).
  • Exploration of sophisticated computational analyses for integrating multi-omics data.

Main Results:

  • 'Omics' technologies generate vast amounts of data on CRC molecular determinants.
  • Sophisticated computational analyses enable integration of diverse 'omics' data.
  • Improved mechanistic understanding derived from integrated data offers new insights into CRC biology.

Conclusions:

  • Technological advances and integrated data analysis are crucial for overcoming CRC heterogeneity.
  • Personalized medicine approaches for CRC management are becoming increasingly feasible.
  • Future CRC clinical management may be tailored to the individual patient based on molecular profiles.
Keywords:
Colorectal cancerGenomicsMetabolomicsPersonalized medicineProteomicsTranscriptomics

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