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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Alternative splicing in cancers: From aberrant regulation to new therapeutics

Xiaowei Song1, Zhenyu Zeng2, Huanhuan Wei3

  • 1CAS Key Lab for Computational Biology, CAS Center for Excellence in Molecular Cell Science, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Department of Cardiology, Changhai Hospital, 168 Changhai Road, Shanghai 200433, China.

Seminars in Cell & Developmental Biology
|September 19, 2017
PubMed

Insights

Alternative splicing regulates gene expression and protein complexity. This review explores its dynamic role in cancer, focusing on RNA splicing factors and novel RNA types in tumorigenesis and potential therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Alternative splicing is a key mechanism for human gene regulation, increasing proteomic diversity.
  • Dysregulation of alternative splicing is increasingly recognized in various human cancers.

Purpose of the Study:

  • To provide a comprehensive review of the link between alternative splicing and tumorigenesis.
  • To highlight the roles of RNA splicing factors in cancer development.
  • To discuss emerging areas like long noncoding RNA and circular RNA splicing in cancer.

Main Methods:

  • Literature review and synthesis of recent research findings.
  • Discussion of regulatory mechanisms of alternative splicing.
  • Analysis of the impact of splicing factors on cancer.

Main Results:

  • Alternative splicing regulation is dynamic and crucial in cancer progression.
  • Specific RNA splicing factors significantly influence tumorigenesis.
  • Long noncoding RNAs and circular RNAs present new avenues in cancer splicing research.

Conclusions:

  • Understanding alternative splicing in cancer is vital for developing targeted therapies.
  • Manipulating alternative splicing offers promising therapeutic strategies for cancer treatment.
Keywords:
Alternative splicingCancerEngineered splicing factorsRNA-binding protein

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