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Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
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Corticothalamic network dysfunction and Alzheimer's disease.

Rohan Jagirdar1, Jeannie Chin1

  • 1Memory & Brain Research Center, Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States.

Brain Research
|September 19, 2017
PubMed
Summary
This summary is machine-generated.

Dysregulation of the corticothalamic network may explain diverse Alzheimer's disease (AD) symptoms beyond memory loss. This network

Keywords:
AttentionHippocampusSeizuresSleep maintenanceThalamic reticular nucleusThalamus

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Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Alzheimer's disease (AD) causes progressive cognitive decline, primarily affecting hippocampal memory.
  • AD also presents with attention, processing, and sleep disturbances, with unclear underlying mechanisms.
  • Existing research focuses heavily on hippocampal dysfunction in AD.

Purpose of the Study:

  • To investigate the corticothalamic network's role in diverse cognitive and behavioral alterations in Alzheimer's disease.
  • To identify potential therapeutic targets by understanding the mechanisms of AD-related impairments.

Main Methods:

  • Review of mechanisms by which the corticothalamic network regulates attention, cognition, memory, and sleep.
  • Analysis of how these domains are altered in Alzheimer's disease.
  • Discussion of corticothalamic network dysregulation's link to epileptiform activity in AD models and patients.

Main Results:

  • The corticothalamic network regulates key cognitive and behavioral functions affected in AD.
  • Dysregulation of this network is implicated in attention, cognitive processing, and sleep deficits.
  • Corticothalamic network dysfunction may contribute to seizures observed in Alzheimer's disease.

Conclusions:

  • The corticothalamic network may serve as a common denominator for various Alzheimer's disease-related cognitive and behavioral symptoms.
  • Targeting the corticothalamic network offers potential therapeutic strategies for improving overall function in AD.
  • Understanding corticothalamic network dysregulation provides insight into the multifactorial nature of Alzheimer's disease.