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CD36 in chronic kidney disease: novel insights and therapeutic opportunities

Xiaochun Yang1, Daryl M Okamura2, Xifeng Lu1

  • 1Centre for Nephrology & Urology, Shenzhen University Health Science Center, 3688 Nanhai Avenue, Shenzhen 518060, China.

Nature Reviews. Nephrology
|September 19, 2017
PubMed

Insights

CD36 receptor plays a key role in kidney fibrosis by promoting lipid accumulation in chronic kidney disease (CKD). Blocking CD36 in experimental models prevented kidney injury, suggesting it as a potential therapeutic target.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Biochemistry

Background:

  • CD36, a multifunctional receptor, is upregulated in chronic kidney disease (CKD).
  • It mediates the uptake of lipids and other molecules, influencing cellular processes like inflammation and apoptosis.
  • Renal CD36 is primarily found in tubular epithelial cells, podocytes, and mesangial cells.

Purpose of the Study:

  • To discuss the regulation and post-translational modification of CD36.
  • To elucidate the role of CD36 in renal pathophysiology, particularly in kidney fibrosis.
  • To explore CD36's potential as a biomarker and therapeutic target for kidney fibrosis.

Main Methods:

  • Review of existing literature on CD36 function and regulation.
  • Analysis of CD36 expression patterns in renal tissues, especially in CKD.
  • Examination of experimental models demonstrating the effects of CD36 modulation on kidney injury.

Main Results:

  • CD36 facilitates intracellular lipid accumulation in the kidney, a key factor in fibrosis development.
  • Reduced fatty acid oxidation in CKD disrupts lipid metabolism, exacerbating lipid accumulation.
  • Experimental CD36 blockade or genetic knockout protects against kidney injury.

Conclusions:

  • CD36 is critically involved in the pathogenesis of kidney fibrosis.
  • Targeting CD36 offers a promising therapeutic strategy for preventing or treating kidney fibrosis.
  • CD36 may serve as a valuable biomarker for kidney disease progression.

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