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Lactobacillus rhamnosus GG: An Overview to Explore the Rationale of Its Use in Cancer
Giuseppe L Banna1, Francesco Torino2, Francesco Marletta3
1Division of Medical Oncology, Cannizzaro HospitalCatania, Italy.
Frontiers in Pharmacology
|September 19, 2017
Summary
Lactobacillus rhamnosus GG (LGG) may help prevent and manage cancer treatment-related diarrhea. Preclinical studies show LGG can reduce inflammation and improve gut health, potentially enhancing patient quality of life.
Area of Science:
- Oncology
- Gastroenterology
- Microbiology
Background:
- Cancer is a leading cause of death, with precision medicine improving outcomes.
- Cancer therapies, especially chemotherapy and radiotherapy, can cause severe side effects like diarrhea.
- Diarrhea negatively impacts patient quality of life and treatment adherence.
Purpose of the Study:
- To review preclinical evidence on Lactobacillus rhamnosus GG (LGG) in cancer.
- To explore LGG's potential role in preventing and managing cancer treatment-related diarrhea.
- To assess LGG's impact on cancer cell proliferation and tumor invasion.
Main Methods:
- Literature review of preclinical studies on LGG and cancer.
- Analysis of LGG's effects on intestinal dysbiosis and inflammation.
- Evaluation of LGG's impact on cancer cell proliferation and invasion in preclinical models.
Main Results:
- LGG can reverse intestinal dysbiosis and moderate diarrhea.
- Preclinical data suggest LGG reduces chronic inflammation linked to cancer.
- LGG shows potential in affecting cancer cell proliferation and tumor invasion.
Conclusions:
- LGG demonstrates promise for managing cancer treatment-induced diarrhea.
- Further clinical investigation of LGG in specific cancer patient populations is warranted.
- LGG may improve treatment adherence and quality of life for cancer patients experiencing diarrhea.
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