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Updated: Feb 22, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Expression of nectin 3: Novel prognostic marker of lung adenocarcinoma
Yoshimasa Maniwa1, Wataru Nishio1, Yutaka Okita1
1Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, JapanDivision of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Background:
We investigated the prognostic significance of the immunoglobulin-like cell adhesion molecule nectin-3, a regulator of the formation of adherens junctions, in human lung adenocarcinoma.
Methods:
Tumor-tissue samples of 127 patients with surgically resected lung adenocarcinoma were used for analysis of the proteins expression by immunohistochemistry.
Results:
Of the 127 patients, 25% showed membranous expression of nectin-3, and others showed negative or cytoplasmic expression. Membranous expression of nectin-3 was found to be a prognostic factor for decreased overall survival on univariate analysis (P = 0.001). Multivariate Cox proportional hazards model analyses also revealed that membranous expression of nectin-3 turned out to be an independent prognostic factor (P = 0.048). Moreover, in tumors expressing membranous nectin-3, some tumors did not co-localize with E-cadherin, and the patients of such tumors showed poorer prognosis than other patients for overall survival on univariate analysis (P < 0.03). Conversely, membranous expression of nectin-3 with E-cadherin co-localization was found to associate with good prognosis of patients.
Conclusion:
Membranous expression of nectin-3 was an independent prognostic factor of lung adenocarcinoma, and it might play an important role in progression of the tumor.
