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Published on: December 9, 2015
Recurrence of disease activity during pregnancy after cessation of fingolimod in multiple sclerosis
Ingrid Meinl1, Joachim Havla1, Reinhard Hohlfeld2
1Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
Background:
Fingolimod is an effective treatment for active relapsing-remitting multiple sclerosis (MS). Discontinuation of therapy may be followed by recurrence of disease activity. Thus, female MS patients may be at risk of relapse during pregnancy after stopping fingolimod.
Objectives And Methods:
To report the disease course during pregnancy of five women who interrupted therapy with fingolimod for pregnancy.
Results:
All patients experienced relapses during pregnancy and/or postpartum after stopping fingolimod.
Conclusion:
The risk of recurrence of disease activity during pregnancy after stopping fingolimod may be substantial. This should be considered and discussed with MS patients who are planning to become pregnant.
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