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Antagonistic effect of somatostatin on corticotropin-releasing factor-induced anorexia in the rat
T Shibasaki1, Y S Kim, N Yamauchi
1Department of Medicine, Institute of Clinical Endocrinology, Tokyo, Japan.
Life Sciences
|January 1, 1988
Abstract:
The effect of somatostatin on corticotropin-releasing factor (CRF)-induced anorexia was examined in rats. Intracerebroventricular (icv) administration of 0.11 nmol and 0.21 nmol ovine CRF significantly suppressed food intake of 24 h-starved rats. Icv administration of 0.31 nmol somatostatin 14 and somatostatin 28 partially reversed suppression of food intake induced by icv injection of 0.21 nmol CRF in 24 h-starved rats. These results suggest that somatostatin may counteract the suppressive effect of CRF on food intake within the central nervous system.