Regulation of hepatic glucose output by glucose in vivo

The effect of infusing glucose at a rate estimated to equal hepatic glucose production (2 mg/kg BW X min) was investigated in postabsorptive unrestrained miniature pigs. Glucose turnover was estimated by the use of 3-H-glucose before and during glucose infusion where the contribution of the glucose-induced hormonal changes were estimated by infusing glucose plus somatostatin with or without insulin and/or glucagon substitution. Our data give evidence for an inhibitory effect of glucose on endogenous glucose production in the postabsorptive state. This effect seems to be independent of the hormonal changes induced by glucose infusion.