Clonidine premedication for sevoflurane anesthesia in upper abdominal surgery
Koh Shingu1, Yasushi Iwatani2, Hidekatsu Furutani2
1Division of Emergency Medicine, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, 606, Kyoto, Japan.
Journal of Anesthesia
|September 19, 2017
Summary
Clonidine, a preanesthetic medication, improved sevoflurane anesthesia in upper abdominal surgery by reducing hypertension and postoperative pain compared to diazepam. Patients pretreated with clonidine experienced better outcomes.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Preanesthetic medication choice impacts anesthetic course and patient outcomes.
- Sevoflurane is a common anesthetic agent for major surgeries.
Purpose of the Study:
- To compare the effects of clonidine versus diazepam as preanesthetic medications on sevoflurane anesthesia during upper abdominal surgery.
Main Methods:
- A randomized study of 22 patients undergoing upper abdominal surgery.
- Groups received either atropine plus clonidine or atropine plus diazepam preoperatively.
- Anesthesia maintained with sevoflurane, nitrous oxide, oxygen, and fentanyl infusion.
Main Results:
- Fewer patients (1/11) in the clonidine group required vasodilators for hypertension versus the diazepam group (7/11).
- Post-extubation pain scores were significantly lower in the clonidine group.
- Recovery of consciousness was similar between groups.
Conclusions:
- Clonidine is a beneficial preanesthetic agent for sevoflurane anesthesia in upper abdominal surgery.
- Clonidine effectively manages intraoperative hypertension and reduces postoperative pain.
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