Natural and Artificial Mn₄ Ca Cluster for the Water Splitting Reaction

The oxygen-evolving center (OEC) in photosystem II (PSII) is a unique biological catalyst that splits water into electrons, protons, and O₂ by using solar energy. Recent crystallographic studies have revealed that the structure of the OEC is an asymmetric Mn₄ Ca cluster, which provides a blueprint to develop man-made water-splitting catalysts for artificial photosynthesis. Although it is a great challenge to mimic the whole structure and function of the OEC in the laboratory, significant advances have recently been achieved. In this Minireview, recent progress on mimicking the natural OEC is discussed. New strategies are suggested to construct more stable and efficient new generation of catalytic materials for the water splitting reaction based on the artificial Mn₄ Ca cluster in the future.