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Tacrolimus Ointment for Refractory Posterior Blepharitis
Fernando Eiji Sakassegawa-Naves1, Helena Maria Moraes Ricci2,3, Bernardo Kaplan Moscovici2,4
1a Department of Ophthalmology , Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo , São Paulo , Brazil.
Current Eye Research
|September 19, 2017
Summary
Topical 0.03% tacrolimus ointment shows promise for refractory posterior blepharitis. This treatment improved ocular surface signs and symptoms like itching and dry eye sensation in a short-term study.
Area of Science:
- Ophthalmology
- Dermatology
Background:
- Posterior blepharitis is a chronic inflammatory condition of the eyelid margins.
- Refractory cases often require novel therapeutic strategies.
Purpose of the Study:
- To evaluate the short-term efficacy of 0.03% tacrolimus ointment for refractory posterior blepharitis.
Main Methods:
- Prospective, randomized, double-blind interventional case series.
- 40 eyes with refractory posterior blepharitis were randomized to 0.03% tacrolimus ointment or placebo.
- Evaluations included questionnaires and slit-lamp examinations at 14 and 28 days.
Main Results:
- Significant improvements were observed in meibomian gland secretion, conjunctival hyperemia, telangiectasia, and ocular staining scores in the tacrolimus group.
- Tacrolimus treatment also led to statistically significant reductions in pruritus and dry eye sensation.
Conclusions:
- Topical 0.03% tacrolimus ointment demonstrates potential as a treatment for refractory posterior blepharitis.
- The ointment may improve both symptomatic and objective signs of the condition.
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