Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corneal changes due to alkali burns.

G Renard, M Hirsch, Y Pouliquen

    Transactions of the Ophthalmological Societies of the United Kingdom
    |September 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Medial closing-wedge distal femoral varus osteotomy: Symptoms and functional impact in cases of associated patellofemoral osteoarthritis. A two-year follow-up prospective pilot study.

    The Knee·2020
    Same author

    Arthroscopic suture repair of acute quadriceps tendon ruptures.

    Orthopaedics & traumatology, surgery & research : OTSR·2017
    Same author

    [The dangers of blue light: True story!].

    Journal francais d'ophtalmologie·2016
    Same author

    [Screening method for angle closure and angle closure glaucoma using scanning laser polarimeter GDxVCC and photodynamic gonioscopy in a darkened room. One-year outcomes of systematic peripheral iridotomy].

    Journal francais d'ophtalmologie·2013
    Same author

    [The irido-corneo-endothelial syndrome. The loss of the control of corneal endothelial cell cycle. A review].

    Pathologie-biologie·2012
    Same author

    [Severe bacterial keratitis referred to ophthalmology emergency departments: a retrospective study of 268 cases].

    Journal francais d'ophtalmologie·2012
    Same journal

    Brain stem and cerebellar deficits in eye movement control.

    Transactions of the ophthalmological societies of the United Kingdom·1986
    Same journal

    Strategies in Doppler ultrasound.

    Transactions of the ophthalmological societies of the United Kingdom·1986
    Same journal

    Congenital glaucoma--diagnosis and management.

    Transactions of the ophthalmological societies of the United Kingdom·1986
    Same journal

    Prostaglandins and other eicosanoids: their ocular transport, pharmacokinetics, and therapeutic effects.

    Transactions of the ophthalmological societies of the United Kingdom·1986
    Same journal

    Development of the ciliary body: a brief review.

    Transactions of the ophthalmological societies of the United Kingdom·1986
    Same journal

    Computer automated visual acuity testing for visual screening.

    Transactions of the ophthalmological societies of the United Kingdom·1986
    See all related articles

    Alkali burns severely damage rabbit corneal epithelium and endothelium. Healing occurs over 21 days, but slow endothelial repair may lead to pathological membrane formation.

    Area of Science:

    • Ophthalmology
    • Regenerative Medicine
    • Corneal Biology

    Background:

    • Corneal alkali burns are a common cause of vision loss.
    • Understanding the cellular mechanisms of corneal healing is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate the in vivo healing process of rabbit corneal epithelium and endothelium following alkali-induced injury.
    • To identify factors contributing to slow healing and potential pathological outcomes.

    Main Methods:

    • Induction of corneal epithelial and endothelial damage using 0.5 normal sodium hydroxide in rabbits.
    • In vivo observation and analysis using transmission and scanning electron microscopy.

    Main Results:

    • Intense cellular necrosis observed within the first day post-injury.

    Related Experiment Videos

  • Epithelial healing completed by day 21, with partial conjunctival epithelial transformation.
  • Endothelial healing was significantly slower due to persistent necrosis and inflammatory reactions.
  • Slow cicatrization led to the formation of a retrocorneal membrane.

    • Conclusions:

    • Rabbit corneal alkali burns demonstrate differential healing rates between epithelium and endothelium.
    • Persistent inflammation and necrosis impede endothelial regeneration, potentially causing pathological changes.
    • The formation of a retrocorneal membrane highlights a significant complication of severe corneal injury.