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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Related Experiment Video

Updated: Feb 22, 2026

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
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Budd-Chiari Syndrome.

Tomáš Grus1, Lukáš Lambert2, Gabriela Grusová3

  • 12nd Department of Surgery - Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.

Prague Medical Report
|September 19, 2017
PubMed
Summary

Budd-Chiari syndrome (BCS) is a rare liver disease caused by impaired venous outflow. Early diagnosis and treatment, including anticoagulation and endovascular procedures, significantly improve survival rates and prevent fatal complications like cirrhosis.

Keywords:
Budd-Chiari syndromeCirrhosisHepatic veinInferior vena cavaLiverThrombosis

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Area of Science:

  • Hepatology
  • Vascular Medicine
  • Rare Diseases

Background:

  • Budd-Chiari syndrome (BCS) is a rare condition characterized by impaired hepatic venous outflow.
  • Etiology involves hypercoagulable states, myeloproliferative disorders, and anatomical variations.
  • Untreated BCS has a 90% mortality rate within 3 years due to liver cirrhosis complications.

Purpose of the Study:

  • To provide a comprehensive overview of Budd-Chiari syndrome.
  • To discuss diagnostic modalities and classification systems.
  • To outline current therapeutic strategies and their impact on survival.

Main Methods:

  • Diagnosis relies on imaging (ultrasound, CT, MRI) to confirm venous outflow obstruction and liver changes.
  • Laboratory and hematological tests are crucial for identifying underlying coagulation disorders.
  • Classification based on etiology, clinical course, and morphology aids in management.

Main Results:

  • Survival rates in treated patients vary (42-100%) based on risk factors and treatment choice.
  • Hematological and coagulation disorders are present in up to 75% of BCS patients.
  • Effective management involves a stepwise approach from medical therapy to transplantation.

Conclusions:

  • Budd-Chiari syndrome requires prompt diagnosis and a multi-faceted treatment strategy.
  • Anticoagulation is recommended for all patients.
  • Endovascular interventions, TIPS, and liver transplantation are key therapeutic options.