Statins and Cognition in Parkinson's Disease
Related Experiment Video
Updated: Feb 22, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Benjamin L Deck1, Jacqueline Rick1, Sharon X Xie2
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background:
The relationship between statins and cognition in Parkinson's disease (PD) is poorly understood.
Objectives:
Analyses were performed to determine associations between statin use and cross-sectional and longitudinal cognitive performance in PD.
Methods:
Neuropsychological tests, medication logs, and ratings of functional abilities were collected from 313 PD participants longitudinally.
Results:
At baseline, statin users (SU; N = 129) were older, more likely male, and had shorter PD duration than non-statin users (NSU; N = 184). In Cross-sectional analysis, SU performed better on global cognition, Trails B, semantic fluency, and phonemic fluency tasks. Rate of long-term global cognitive (Dementia Rating Scale-2 and MoCA) decline was significantly less in SU.
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