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Systemic immunosuppression in marginal keratolysis.

D L Easty, P Madden, M I Jayson

Transactions of the Ophthalmological Societies of the United Kingdom

|September 1, 1978

Summary

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Peripheral corneal melting syndrome can be challenging to treat. Short-term, non-corticosteroid immunosuppressive therapy may benefit severe cases unresponsive to other treatments.

Area of Science:

Ophthalmology
Immunology

Background:

Peripheral corneal melting syndrome (PCMS) is a severe ocular condition.
PCMS can lead to significant vision loss and requires effective treatment strategies.

Purpose of the Study:

To describe the experience with eleven patients diagnosed with PCMS.
To evaluate the potential of non-corticosteroid immunosuppressive regimes in managing severe PCMS.

Main Methods:

Retrospective review of eleven patients with PCMS.
Application of short-term, non-corticosteroid immunosuppressive treatments for severe, progressive disease.

Main Results:

Eleven patients with PCMS were investigated and treated.
The study suggests that non-corticosteroid immunosuppressive regimes are a viable option for severe PCMS.

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Conclusions:

Short-term non-corticosteroid immunosuppressive therapy should be considered for severe, progressive PCMS.
This treatment approach may be effective in cases refractory to other therapies.