Related Experiment Video

Updated: Feb 22, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

29.4K

Clinical evaluation of the newly formatted lateral-flow device for invasive pulmonary aspergillosis

Martin Hoenigl1,2,3,4, Susanne Eigl1, Sven Heldt1

  • 1Division of Pulmonology, Medical University of Graz, Graz, Austria.

Mycoses
|September 19, 2017
PubMed

Insights

A new Aspergillus-specific lateral-flow-device (LFD) shows improved performance for diagnosing invasive pulmonary aspergillosis (IPA). The enhanced LFD test demonstrated higher specificity and sensitivity in patient samples compared to the original prototype.

Area of Science:

  • Medical diagnostics
  • Mycology
  • Infectious diseases

Background:

  • Invasive pulmonary aspergillosis (IPA) is a serious fungal infection.
  • Accurate and rapid diagnostic tools for IPA are crucial for timely treatment.
  • Existing diagnostic methods, including earlier lateral-flow-device (LFD) prototypes, have limitations.

Purpose of the Study:

  • To evaluate the diagnostic performance of a newly formatted Aspergillus-specific LFD.
  • To compare the new LFD test against the original prototype LFD.
  • To assess the utility of the new LFD in bronchoalveolar lavage fluid (BALF) samples.

Main Methods:

  • The study utilized BALF samples from 28 patients.
  • Patients were categorized into two groups: 14 with probable/proven IPA and 14 without evidence of IPA.
  • Performance metrics (sensitivity and specificity) of the new LFD were compared to the old LFD prototype.

Main Results:

  • The new LFD correctly identified 10 out of 14 (71%) BALF samples from IPA patients.
  • It achieved true-positive results in 8/9 cases previously false-negative with the old LFD.
  • All 14 samples from non-IPA patients tested negative with the new LFD, indicating improved specificity.

Conclusions:

  • The newly formatted Aspergillus-specific LFD demonstrates enhanced diagnostic accuracy for IPA.
  • The improved specificity of the new LFD reduces the likelihood of false-positive results.
  • This new LFD holds promise as a more reliable tool for diagnosing IPA.
Keywords:
Haematological malignancybronchoalveolar lavagegalactomannanintensive care unitpoint-of-care

More Related Videos

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

11.1K
Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung15:01

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung

Published on: September 18, 2021

3.8K

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
560
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
954
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.2K
Sputum Studies II: Culture and Sensitivity01:20

Sputum Studies II: Culture and Sensitivity

Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
1.4K