Related Experiment Video

Updated: Feb 22, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

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Current updates on microRNAs as regulators of chemoresistance

Metin Çalışkan1, Hale Güler1, Vildan Bozok Çetintaş1

  • 1Department of Medical Biology, Ege University School of Medicine, Izmir, Turkey.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 20, 2017
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in cancer, influencing gene expression and impacting chemotherapy resistance. This review explores their role in overcoming treatment challenges, offering new therapeutic avenues.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Chemotherapy resistance is a major obstacle in cancer treatment, affecting drugs like platinum agents and topoisomerase inhibitors.
  • Multiple resistance mechanisms exist, driving the need for novel strategies to improve patient outcomes.
  • MicroRNAs (miRNAs) are crucial post-transcriptional gene regulators implicated in cancer development and progression.

Purpose of the Study:

  • To review the role of miRNAs in the development of chemotherapy resistance.
  • To summarize research findings on miRNAs and chemoresistance from January 2015 to June 2017.
  • To highlight the potential of miRNAs as therapeutic targets for overcoming cancer drug resistance.

Main Methods:

  • Literature review of scientific articles published between January 2015 and June 2017.
  • Focus on studies investigating the involvement of miRNAs in chemotherapy resistance mechanisms.
  • Synthesis of findings related to miRNA dysregulation and its impact on treatment response.

Main Results:

  • Dysregulated miRNAs are frequently observed in various cancers, affecting tumorigenesis, diagnosis, and prognosis.
  • Specific miRNAs have been identified as key players in mediating resistance to diverse chemotherapeutic agents.
  • miRNAs show promise in improving the prediction of patient outcomes and response to chemotherapy.

Conclusions:

  • miRNAs represent promising biomarkers for predicting chemotherapy response and patient prognosis.
  • Targeting miRNAs offers a novel therapeutic strategy to overcome chemoresistance in cancer.
  • Further research into miRNA functions is essential for developing effective chemoresistance-breaking treatments.
Keywords:
ChemoresistanceMicroRNAMicrotubule inhibitorsNucleoside analoguesPlatinum agentsTopoisomerase inhibitors

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