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Related Experiment Videos

Positive bethanechol supersensitivity test in neurologically normal patients.

J S Wheeler1, D J Culkin, J R Canning

  • 1Department of Urology, Loyola University Medical Center, Maywood, Illinois.

Urology
|January 1, 1988
PubMed
Summary

A positive bethanechol supersensitivity test (BST) may not reliably diagnose neuropathic detrusor areflexia. Many factors can cause false positives, necessitating a comprehensive neurourologic evaluation.

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Area of Science:

  • Urology
  • Neurology

Background:

  • A positive bethanechol supersensitivity test (BST) typically suggests neuropathic detrusor areflexia.
  • Neurologic correlation is usually recommended for positive BST results.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of the BST in patients presenting with symptoms of detrusor areflexia.
  • To investigate potential confounding factors affecting BST results.

Main Methods:

  • Seven female patients with straining to void and high residual urines underwent BST.
  • Patients with borderline or positive BST results (19-55 cm H2O change) were assessed with neurologic workups.

Main Results:

  • All patients exhibited normal neurologic findings, despite borderline or positive BST results.

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  • Two patients had minor spina bifida occulta, and two had prior pelvic surgery.
  • Four patients had psychosocial issues, known to influence BST outcomes.
  • The study identified several variables that can lead to false-positive BST results.

    • Conclusions:

    • The bethanechol supersensitivity test is not definitively diagnostic for neurogenic detrusor areflexia.
    • A comprehensive neurourologic evaluation is crucial for accurate diagnosis, considering potential BST confounding factors.